PMC

Distribution of creatinine values pre- and post-correction for each specimen type and creatinine method compared to ID-LCMS. A IDMS venous vs Cobas plasma correction. B IDMS venous vs dimension plasma correction. C IDMS venous vs Vitros plasma correction. D IDMS venous vs BCMS venous correction. E IDMS capillary vs BCMS capillary correction. F IDMS venous vs BCMS capillary correction

Mean values of CBF calculated from arterial (solid lines) and capillary (dashed lines) blood measurements versus gestational age: a capillary pO₂ values without correction; b capillary pO₂ measurements corrected with mean difference (dashed lines without symbols: pO₂^cap + 15.15 mmHg) or with linear regression (circles: 0.64·pO₂^cap + 28.32 mmHg)

Concordance between capillary VAMS samples, venous VAMS samples and calculated serum (based on a blood-serum and capillary-venous correction factor). (a) ADM (μg/mL) in the three matrices, capillary VAMS samples, venous VAMS samples and serum. Green range represents the therapeutic window of ADM (3.51–7.0 μg/mL [,]) (b) Pearson correlation of ADM concentrations obtained from serum samples (X-axis) and calculated ADM serum concentrations based on a blood-serum correction factor of 1.22 and a capillary correction factor of 1.28 (Y-axis). (c) ADM (μg/mL) in serum (gold standard) and calculated ADM serum concentration, based on a blood-serum correction factor of 1.22 and a capillary-venous correction factor of 1.28. Green range represents the therapeutic window of ADM (3.51–7.0 μg/mL [,]). Abbreviations: ADM—adalimumab; CI—confidence interval; N—number of samples; VAMS—volumetric absorptive microsampling.

3D CBFv network image of mouse sensorimotor cortex (2.4 × 2.0 × 1.4 mm³) before and after θ_z correction. (a) Raw 3D μODT image (i.e., v_z) without θ_z correction, (b) 3D Doppler angle θ_z image, (c) 3D absolute v_RBC image after θ_z correction by 3D Hessian matrix. Yellow arrow: horizontally oriented capillary flow in deep cortex usually undetectable without angle correction; white arrows: correction of pial flows. 2D pie-cut images are MIP images of 200 μm-thick sub-volume.